منابع مشابه
FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils.
RATIONALE Platelets are the most important cells in the primary prevention of blood loss after injury. In addition, platelets are at the interface between circulating leukocytes and the (sub)endothelium regulating inflammatory responses. OBJECTIVE Our aim was to study the dynamic process that leads to the formation of procoagulant and proinflammatory platelets under physiological flow. METH...
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Exposure of live cells to shear flow induces major changes in cell shape, adhesion to the extracellular matrix, and migration. In the present study, we show that exposure of cultured multiple myeloma (MM) cells to shear flow of 4-36 dynes/cm(2) triggers the extension of long tubular protrusions (denoted flow-induced protrusions, or FLIPs) in the direction of the flow. These FLIPs were found to ...
متن کاملCell Protrusions
Introduction How do cells move? There is no shortage of theories, but a definitive answer is still elusive. Here we will present some models for cell motions along with proposals for experiments to address the theories. We will restrict ourselves to the problem of cell protrusion, although the models apply to other motility phenomena as well. Different protrusion phenomena extend at different c...
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Magnetic tweezers were used to study the passive and active response of macrophages to local centripetal nanonewton forces on beta1 integrins. Superparamagnetic beads coated with the beta1-integrin-binding protein invasin were attached to J774 murine macrophages to mimic phagocytosis of bacterial pathogens. Forces exceeding approximately 0.5 nN induce the active formation of trumpet-like protru...
متن کاملLumbar disc protrusions in pregnancy.
The occurence of paralysis of a lower limb of the mother after labour was first described at least 120 years ago (von Basedow, 1838). The condition is uncommon, Beattie (1933) reporting an incidence of less than 1 in 2,500 deliveries. This "maternal obstetrical palsy", as it has been named, has usually been considered to result from injury to the lumbosacral plexus occasioned by the foetal head...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.114.302361